Biomed Research International

Call for papers

Biomed Research International

Special Session @
Modelling Cochlear Mechanics: Insights into the Physiology and Pathology of the Inner Ear


The clinical evidence indicates that the number of people with sensorineural hearing loss is rising, mainly due to a growing global population and longer life expectancies. Understanding the exact pathophysiological consequences and mechanisms through which diverse causative factors give rise to hearing impairment in humans requires a thorough understanding of the normal function of the cochlea. However, the study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible. Mathematical models have been recently introduced into the study of cochlear physiology and pathology, giving insight into the system’s behaviour and attributes that would have been impossible to have with human in-vivo studies. Moreover, such models can serve as a powerful platform to study the structure-function relationship in normal and pathological ears as well as give insights into the planning of novel surgical procedures for the rehabilitation of sensorineural hearing loss, paving the way for individualised assessment decision making and treatment planning resulting to more personalized healthcare.  

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand cochlear mechanics through mathematical modelling approaches, providing a framework for measuring cochlear features, explaining wave propagation and modelling dynamics of fluids in the inner-ear channels. We are particularly interested in articles describing use of models to predict pathological features or to design new audiological investigations or novel therapeutic approaches. We are also interested in multi-scale modelling of the inner ear, developing heterogenous model alignment strategies, and methods for clinical validation of the models.

Topics of interest
Potential topics include, but not limited to:

  • Geometry model reconstruction of the cochlea and 3-D visualization tools
  • Multi-scale modelling of the inner ear
  • Continuum and discrete modelling of the inner ear
  • Recent developments in modelling electrical coupling within the cochlea
  • Recent advances in bone conduction modelling
  • Construction of personalised models to aid in diagnosis and management of hearing loss
  • Use of cochlear models to design novel surgical procedures
  • Clinical validation of inner ear models


Paper submission
Before submission, authors should carefully read over the journal’s Author Guidelines, which are located at guidelines page. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at official web page according to the following timetable:

Manuscript Due    September 20, 2013
First Round of Reviews   December 13, 2013
Publication Date   February 7, 2013


Lead Guest Editor
Athanasios Bibas
Department of Otolaryngology
University of Athens, Greece
thanosbibas@hotmail.com


Guest Editors
Steven Elliot
Institute of Sound and Vibration
University of Southampton
Southampton, UK
S.J.Elliott@soton.ac.uk

Stefan Stenfelt
Department of Clinical and Experimental Medicine
Linköping University
Linköping, Sweden
stefan.stenfelt@liu.se

Nenad Filipovic
Bioengineering Research and Development Center (BioIRC)
Kragujevac, Serbia
fica@kg.ac.rs